Endocrine Abstracts

Background: Investigating the origin of ACTH determine disparate treatment and prognosis in ACTH-dependent Cushing’s Syndrome. We want to detect the value of combination of HDDST and DDAVP stimulation test for identifying Cushing’s disease (CD) and Ectopic ACTH-dependent Cushing’s Syndrome (EAS).Methods: We retrospectively recorded 102 ACTH-dependent Cushing’s Syndrome (87 CD and 15 EAS) in West China Hospital from January 1, 2010...

Summary: Objective: To evaluate the expression level and binding affinity of glucocorticoid receptors (GRs)in patients with endogenous Cushing’s syndrome(CS) and to determine whether there is partial glucocorticoid resistance.Methods: Fifty-eight patients with CS and forty-one age- and sex-matched healthy volunteers were studied. The expression level and binding affinity of GRs in peripheral blood mononuclear cells (PBMLs) were examined by flow cyt...

Objective: This systematic review aimed to assess the efficacy and safety of testosterone replacement therapy (TRT) in obese men with testosterone deficiency through the analysis of randomized controlled trials (RCTs).Materials and Methods: A comprehensive computer-based search was conducted in Cochrane Library, PubMed, Embase, Web of Science, Scopus, Open SIGLE database, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP database, and Chi...

Background and purpose: Obese men often exhibit hypoandrogenemia. Although previous research has established obesity and metabolic-related disorders as key factors contributing to decreased androgens in males, there are rare studies to comprehensively understand the correlation between sex hormones and obesity, as well as metabolic indicators, particularly in non Caucasian populations. This study aims to comprehensively investigate the relationship between sex hormones and obe...

Background: Patients with acromegaly have an increased risk of vertebral fractures, yet normal or elevated bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA). This suggests that DXA may not be a reliable tool for assessing BMD in acromegalic patients. Multiple studies have suggested that patients with acromegaly have compromised trabecular bone but not cortical bone. Quantitative computed tomography (QCT) represents a three-dimensional technique for quantifyi...

Objective: To examine the relationship between C-peptide levels and endogenous insulin secretion and to understand the effects of elevated C-peptide after dosing on evaluating study insulin and its analogs’ PK/PD values in euglycemic clamps.Method: The study included 33 healthy male volunteers who underwent an 8-h euglycemic clamp with a subcutaneous injection of insulin aspart (0.2 U/kg). Blood glucose (BG), C-peptide, human insulin, and insu...

Objective: Studies have demonstrated that patients with acromegaly have compromised bone health and an increased risk of vertebral fractures (VFs). However, the prevalence of VFs in Chinese patients with acromegaly has not been investigated by far. This study aimed to evaluate the prevalence and determinants of VFs in patients with acromegaly in a tertiary hospital in China.Methods: We enrolled patients diagnosed with acromegaly consecutively at West Chi...

Objective: To summarise and analyze the pathogenesis, clinical risk assessment, and treatment of venous thromboembolic events (VTE) associated with Cushing syndrome (CS), and to improve clinicians’ understanding of this complication.Methods: The clinical diagnosis and treatment of 3 patients with Cushing disease (CD) combined with pulmonary embolism were reviewed, and relevant literature at home and abroad was reviewed.Results...

Background: Cushing’s disease (CD) is associated with hypercortisolism-induced cardiovascular morbidity and mortality and impaired patient quality of life (QoL). We report long-term effects of osilodrostat (potent 11β-hydroxylase inhibitor) on cardiovascular/metabolic-related risk factors, physical features of hypercortisolism and QoL in CD patients following the core and extension phases of the LINC 4 study (NCT02697734).Methods: LINC 4 compri...

Background: Pasireotide has proven efficacy in acromegaly and CD, although pasireotide-associated hyperglycaemia occurs in some patients. This Phase IV, randomized, open-label study investigated optimal management of pasireotide-associated hyperglycaemia uncontrolled by metformin/oral antidiabetic therapy (OAD) [NCT02060383].Methods: Adults with acromegaly or CD were enrolled and treated with long-acting pasireotide 40 mg/28 days or subcutaneous pasireot...